Nurse Practitioner vs Physician Assistant: What's the Difference?


The roles of Nurse Practitioners (NPs) and Physician Assistants (PAs) are both crucial in delivering healthcare services, especially in primary care and underserved areas. While their responsibilities often overlap, there are key differences in their training, approach, and scope of practice.
Read on to learn the differences in NPs vs PAs when it comes to educational background, scope of practice, salary and more.
Popular Online Nurse Practitioner (NP) Programs

Chamberlain University is the #1 largest school of nursing with a community of more than 177,000 students, faculty, and alumni. Chamberlain offers BSN, MSN, and DNP programs online and has a long history of successfully delivering top quality education.
Enrollment: Nationwide

Earn your nursing degree from one of the largest nursing education providers in the U.S. Walden University’s BSN, MSN, post-master’s APRN certificate, and DNP programs are accredited by the Commission on Collegiate Nursing Education (CCNE). Get enhanced practicum support with our Practicum Pledge.
Enrollment: Nationwide, excluding CT, NY and RI. Certain programs have additional state restrictions. Check with Walden for details.

Georgetown University is one of the world’s leading academic and research institutions, and the School of Nursing has been delivering graduate nursing programs in a distance-learning environment since 2011. Georgetown's online programs allow students to learn from wherever they are while they pursue an accredited, mission-driven nursing education that will allow them to deliver high-quality care.
Enrollment: Nationwide, excluding NY and WA.

WGU's award-winning online programs are created to help you succeed while graduating faster and with less debt. WGU is a CCNE-accredited, nonprofit university offering bachelor's and master's degrees in nursing, with the additional distinction of being named a Center of Excellence in Nursing Education by the National League for Nursing. Join a trusted, accredited online university to accelerate your nursing career on your schedule. Scholarships and financial aid are available.
Enrollment: Nationwide
Nurse Practitioner vs Physician Assistant: What's the Difference?
What is a Nurse Practitioner (NP)?
A nurse practitioner is an advanced practice registered nurse (APRN) who has additional responsibilities for administering patient care than RNs. NP model draws from the nursing tradition, one that includes a whole person and wellness approach.
Responsibilities:
- Perform physical exams and take patient histories
- Diagnose and manage acute and chronic conditions
- Order and interpret diagnostic tests
- Prescribe medications and treatments
- Educate patients on health maintenance and disease prevention
- Provide immunizations and routine screenings
- Advocate for patients and coordinate care
- Collaborate with healthcare teams or work independently
- Maintain accurate medical records
- Engage in continuing education and professional development
What is a Physician Assistant (PA)?
A physician assistant is a master's-prepared individual who works interdependently with licensed physicians to diagnose and treat illness and disease and prescribe medication for patients. The PA tradition draws from a medical model.
Responsibilities:
- Conduct physical exams and obtain medical histories
- Diagnose illnesses and develop treatment plans
- Order and interpret lab tests and imaging
- Prescribe medications and therapies
- Assist in surgeries and perform medical procedures
- Provide patient education and counseling
- Monitor and manage ongoing patient care
- Collaborate closely with supervising physicians
- Document patient information and clinical findings
- Stay current with medical knowledge and certification requirements
NP vs PA Comparison
Nurse Practitioner (NP) | Physician Assistant (PA) | |
Duties | NPs are healthcare providers who can prescribe medication, examine patients, order diagnostic tests, diagnose illnesses, and provide treatment, much like physicians do. In certain states, they can work independently from a physician. |
PAs have the ability to treat patients independently of a medical physician. They perform a variety of duties, including writing prescriptions, ordering and interpreting laboratory tests, assisting in surgery, performing minor bedside procedures, diagnosing patients, developing treatment plans, and obtaining patient histories. |
Salary | $129,210 / year (BLS) | $133,260 / year (BLS) |
Education | Master's degree | Master's degree |
Program Costs | $35,000 - $70,000 | $60,000 to $90,000 |
Scope of Practice |
Can operate own practice in certain states. |
Can operate own practice in certain states. |
Career Outlook | 38% predicted career growth from 2023-2033 | 28% predicted career growth from 2023-2033 |
Certification |
NP recertification is every five years and requires the following:
|
PA recertification has two parts:
|
NP vs. PA Primary Differences
The main differences between nurse practitioners (NPs) and physician assistants (PAs) lie in their educational backgrounds, approach to care, and scope of practice.
Training & Approach
- NPs are trained in the nursing model, which emphasizes patient-centered care, health promotion, and disease prevention, and they typically specialize in specific populations (e.g., family, pediatrics, geriatrics).
- PAs, on the other hand, are educated in the medical model, similar to physicians, with a focus on disease pathology and diagnosis across all populations.
Scope of Practice
Both NPs and PAs can diagnose conditions, prescribe treatments, and work independently in many states. However, there are some differences in their scope of practice:
- NPs often have more autonomy in practice, especially in states with full practice authority.
- PAs generally work under a physician's supervision, though the degree of oversight varies by state and employer.
Nurse Practitioner vs Physician Assistant Education Requirements
Program length is roughly the same for both a PA vs an NP after earning a bachelor’s degree. Both tracks consist of master’s level programs that students can complete in 2-3 years, depending on the specific program.
Nurse Practitioner Education
- Background: NPs begin as RNs, typically earning a Bachelor of Science in Nursing.
- Graduate Degree: They then pursue a Master of Science in Nursing or Doctor of Nursing Practice, which includes advanced coursework in pathophysiology, pharmacology, clinical assessment, and population-based care.
- Clinical Hours: NP programs typically require 500–700+ supervised clinical hours, depending on the specialization.
Physician Assistant Education
- Background: PAs generally come from varied science or healthcare backgrounds, often holding a bachelor’s degree in a science-related field (not necessarily nursing).
- Graduate Degree: They complete a Master’s in Physician Assistant Studies (MPAS, MPA, or similar), which usually takes about 2–3 years.
- Clinical Rotations: PAs complete approximately 2,000 hours of supervised clinical rotations across multiple specialties (e.g., internal medicine, surgery, emergency medicine).
NP vs PA Work Environments
NPs and PAs can work in many of the same environments, but there are some differences:
Work Location | Nurse Practitioner (NP) | Physician Assistant (PA) |
Hospitals, acute, or ambulatory care settings | ✓ | ✓ |
Outpatient care centers | ✓ | ✓ |
Long-term care facilities and nursing homes | ✓ | |
Private homes providing health care services | ✓ | |
Hospice and palliative care services | ✓ | |
Government and community health agencies | ✓ | ✓ |
Universities and research agencies | ✓ | ✓ |
Healthcare or health industry businesses | ✓ | ✓ |
Private practice | ✓ | |
Phone triage centers | ✓ | ✓ |
Rural healthcare facilities | ✓ | ✓ |
Nurse-managed medical centers | ✓ | ✓ |
Physician offices | ✓ | |
Employment service offices | ✓ | |
Urgent care centers | ✓ | |
Surgery centers and surgical departments | ✓ | |
Psychiatric hospitals | ✓ | |
Orthopedics | ✓ | |
Dermatology | ✓ | |
Pathology | ✓ | |
Emergency medicine and critical care | ✓ | |
Adolescent and pediatric medicine | ✓ |
NP vs PA Scope of Practice
The nurse practitioner vs physician assistant scope of practice has subtle yet vital differences. For starters, NP education requires students to select a specialty that will prepare them to serve a specific population. Physician assistants have a broader, more general medical background.
But PAs may also specialize. Often, physician assistants choose a surgical specialty, while NPs work mostly at the patient's bedside throughout their hospitalization.
Physician Assistant Scope of Practice
The American Academy of Physician Assistants reveals that a PA's scope of practice is often decided at the practice level rather than by the state. Although physician assistants take on many of the responsibilities of general physicians, the two have key differences.
PAs collaborate with general physicians to perform patient examinations, diagnose and treat illnesses, prescribe medications, and perform other day-to-day medical services. Similar to a nurse practitioner, PAs can also practice independently of a physician in certain states.
Nurse Practitioner Scope of Practice
In 23 states, nurse practitioners have “full practice authority,” which means they do not have to work under the supervision of a doctor. US states with nurse practitioner full practice authority include but aren't limited to:
- Oregon
- Maine
- Alaska
- Hawaii
- Washington
- Iowa
In states with reduced practice (Ohio, Pennsylvania, and Utah) and restricted practice (Texas, California, and Florida), NPs must have a medical doctor sign certain medical patient care decisions. NPs have prescriptive privileges in all 50 states and can administer controlled substances in 49 states.
NP vs PA Career Outlook
According to the US Bureau of Labor Statistics, the need for nurse practitioners is expected to grow by 38% by 2033. This is much faster than the national average of other healthcare-related professions, including physician assistants, which are expected to grow in demand by 28%.
NP vs PA Certification
As an NP, you must complete a recertification every five years by completing 1,000 clinical hours in your certified specialty and separate continuing education (CEU) hours. The PA recertification process has two parts, which includes 100 hours of continuing medical education (CME) hours every two years and a recertification exam every 10.
How to Choose Between Becoming a PA or an NP
NPs and PAs both provide direct patient care at the advanced practice level, including working independently or collaboratively. With so many baby boomers aging, the need for more graduate-level healthcare providers is increasing by the day. Plus, the need for these professions has escalated because of the Affordable Care Act, with more than 40 million more people added to the primary care systems after finally getting health insurance in the last two years.
“Physician assistants and nurse practitioners are more cost-effective in a health care system, and there has been an amazing up swell interest in how to integrate them into hospital systems in more and more ways,” says Jonathan Bowser, director and associate dean of the physician assistant program at the University of Colorado Anschutz Medical Campus.
Popular Online Nurse Practitioner (NP) Programs

Chamberlain University is the #1 largest school of nursing with a community of more than 177,000 students, faculty, and alumni. Chamberlain offers BSN, MSN, and DNP programs online and has a long history of successfully delivering top quality education.
Enrollment: Nationwide

Earn your nursing degree from one of the largest nursing education providers in the U.S. Walden University’s BSN, MSN, post-master’s APRN certificate, and DNP programs are accredited by the Commission on Collegiate Nursing Education (CCNE). Get enhanced practicum support with our Practicum Pledge.
Enrollment: Nationwide, excluding CT, NY and RI. Certain programs have additional state restrictions. Check with Walden for details.

Georgetown University is one of the world’s leading academic and research institutions, and the School of Nursing has been delivering graduate nursing programs in a distance-learning environment since 2011. Georgetown's online programs allow students to learn from wherever they are while they pursue an accredited, mission-driven nursing education that will allow them to deliver high-quality care.
Enrollment: Nationwide, excluding NY and WA.

WGU's award-winning online programs are created to help you succeed while graduating faster and with less debt. WGU is a CCNE-accredited, nonprofit university offering bachelor's and master's degrees in nursing, with the additional distinction of being named a Center of Excellence in Nursing Education by the National League for Nursing. Join a trusted, accredited online university to accelerate your nursing career on your schedule. Scholarships and financial aid are available.
Enrollment: Nationwide