Nurse Practitioner vs Physician Assistant: What's the Difference?

7 Min Read Published May 29, 2025
NP vs PA
NP vs PA

The roles of Nurse Practitioners (NPs) and Physician Assistants (PAs) are both crucial in delivering healthcare services, especially in primary care and underserved areas. While their responsibilities often overlap, there are key differences in their training, approach, and scope of practice.

Read on to learn the differences in NPs vs PAs when it comes to educational background, scope of practice, salary and more. 

Popular Online Nurse Practitioner (NP) Programs

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Chamberlain University

Chamberlain University is the #1 largest school of nursing with a community of more than 177,000 students, faculty, and alumni. Chamberlain offers BSN, MSN, and DNP programs online and has a long history of successfully delivering top quality education.

Accreditation
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Location
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Prerequisite
RN Required

Enrollment: Nationwide

Walden University

Earn your nursing degree from one of the largest nursing education providers in the U.S. Walden University’s BSN, MSN, post-master’s APRN certificate, and DNP programs are accredited by the Commission on Collegiate Nursing Education (CCNE). Get enhanced practicum support with our Practicum Pledge.

Accreditation
CCNE
Location
Online
Prerequisite
RN Required

Enrollment: Nationwide, excluding CT, NY and RI. Certain programs have additional state restrictions. Check with Walden for details.

Georgetown University

Georgetown University is one of the world’s leading academic and research institutions, and the School of Nursing has been delivering graduate nursing programs in a distance-learning environment since 2011. Georgetown's online programs allow students to learn from wherever they are while they pursue an accredited, mission-driven nursing education that will allow them to deliver high-quality care.

Accreditation
CCNE
Location
Online
Prerequisite
RN Required

Enrollment: Nationwide, excluding NY and WA.

Western Governors University

WGU's award-winning online programs are created to help you succeed while graduating faster and with less debt. WGU is a CCNE-accredited, nonprofit university offering bachelor's and master's degrees in nursing, with the additional distinction of being named a Center of Excellence in Nursing Education by the National League for Nursing. Join a trusted, accredited online university to accelerate your nursing career on your schedule. Scholarships and financial aid are available. 

Accreditation
CCNE
Location
Online
Prerequisite
RN Required

Enrollment: Nationwide

Nurse Practitioner vs Physician Assistant: What's the Difference?

What is a Nurse Practitioner (NP)? 

A nurse practitioner is an advanced practice registered nurse (APRN) who has additional responsibilities for administering patient care than RNs. NP model draws from the nursing tradition, one that includes a whole person and wellness approach.

Responsibilities:

  • Perform physical exams and take patient histories
  • Diagnose and manage acute and chronic conditions
  • Order and interpret diagnostic tests
  • Prescribe medications and treatments
  • Educate patients on health maintenance and disease prevention
  • Provide immunizations and routine screenings
  • Advocate for patients and coordinate care
  • Collaborate with healthcare teams or work independently
  • Maintain accurate medical records
  • Engage in continuing education and professional development

What is a Physician Assistant (PA)?

A physician assistant is a master's-prepared individual who works interdependently with licensed physicians to diagnose and treat illness and disease and prescribe medication for patients. The PA tradition draws from a medical model.

Responsibilities:

  • Conduct physical exams and obtain medical histories
  • Diagnose illnesses and develop treatment plans
  • Order and interpret lab tests and imaging
  • Prescribe medications and therapies
  • Assist in surgeries and perform medical procedures
  • Provide patient education and counseling
  • Monitor and manage ongoing patient care
  • Collaborate closely with supervising physicians
  • Document patient information and clinical findings
  • Stay current with medical knowledge and certification requirements

NP vs PA Comparison

  Nurse Practitioner (NP) Physician Assistant (PA)
Duties NPs are healthcare providers who can prescribe medication, examine patients, order diagnostic tests, diagnose illnesses, and provide treatment, much like physicians do. In certain states, they can work independently from a physician.

PAs have the ability to treat patients independently of a medical physician. They perform a variety of duties, including writing prescriptions, ordering and interpreting laboratory tests, assisting in surgery, performing minor bedside procedures, diagnosing patients, developing treatment plans, and obtaining patient histories.

Salary $129,210  / year (BLS) $133,260 / year (BLS)
Education Master's degree Master's degree
Program Costs $35,000 - $70,000 $60,000 to $90,000
Scope of Practice

Can operate own practice in certain states.

Can operate own practice in certain states.

Career Outlook 38% predicted career growth from 2023-2033 28% predicted career growth from 2023-2033
Certification

NP recertification is every five years and requires the following:

  • A minimum of 1,000 clinical hours in your certified specialty 
  • 75 continuing education hours

PA recertification has two parts:

  • Complete 100 continuing education hours every two years
  • Pass a recertification exam every ten years

NP vs. PA Primary Differences

The main differences between nurse practitioners (NPs) and physician assistants (PAs) lie in their educational backgrounds, approach to care, and scope of practice.

Training & Approach

  • NPs are trained in the nursing model, which emphasizes patient-centered care, health promotion, and disease prevention, and they typically specialize in specific populations (e.g., family, pediatrics, geriatrics). 
  • PAs, on the other hand, are educated in the medical model, similar to physicians, with a focus on disease pathology and diagnosis across all populations.

Scope of Practice

Both NPs and PAs can diagnose conditions, prescribe treatments, and work independently in many states. However, there are some differences in their scope of practice:

  • NPs often have more autonomy in practice, especially in states with full practice authority.
  •  PAs generally work under a physician's supervision, though the degree of oversight varies by state and employer.

Nurse Practitioner vs Physician Assistant Education Requirements 

Program length is roughly the same for both a PA vs an NP after earning a bachelor’s degree. Both tracks consist of master’s level programs that students can complete in 2-3 years, depending on the specific program.

Nurse Practitioner Education

  • Background: NPs begin as RNs, typically earning a Bachelor of Science in Nursing.
  • Graduate Degree: They then pursue a Master of Science in Nursing or Doctor of Nursing Practice, which includes advanced coursework in pathophysiology, pharmacology, clinical assessment, and population-based care.
  • Clinical Hours: NP programs typically require 500–700+ supervised clinical hours, depending on the specialization.

Physician Assistant Education

  • Background: PAs generally come from varied science or healthcare backgrounds, often holding a bachelor’s degree in a science-related field (not necessarily nursing).
  • Graduate Degree: They complete a Master’s in Physician Assistant Studies (MPAS, MPA, or similar), which usually takes about 2–3 years.
  • Clinical Rotations: PAs complete approximately 2,000 hours of supervised clinical rotations across multiple specialties (e.g., internal medicine, surgery, emergency medicine).

NP vs PA Work Environments

NPs and PAs can work in many of the same environments, but there are some differences:

Work Location Nurse Practitioner (NP) Physician Assistant (PA)
Hospitals, acute, or ambulatory care settings
Outpatient care centers
Long-term care facilities and nursing homes  
Private homes providing health care services  
Hospice and palliative care services  
Government and community health agencies
Universities and research agencies
Healthcare or health industry businesses
Private practice  
Phone triage centers
Rural healthcare facilities
Nurse-managed medical centers
Physician offices  
Employment service offices  
Urgent care centers  
Surgery centers and surgical departments  
Psychiatric hospitals  
Orthopedics  
Dermatology  
Pathology  
Emergency medicine and critical care  
Adolescent and pediatric medicine  

NP vs PA Scope of Practice

The nurse practitioner vs physician assistant scope of practice has subtle yet vital differences. For starters, NP education requires students to select a specialty that will prepare them to serve a specific population. Physician assistants have a broader, more general medical background. 

But PAs may also specialize. Often, physician assistants choose a surgical specialty, while NPs work mostly at the patient's bedside throughout their hospitalization.

Physician Assistant Scope of Practice

The American Academy of Physician Assistants reveals that a PA's scope of practice is often decided at the practice level rather than by the state. Although physician assistants take on many of the responsibilities of general physicians, the two have key differences.

PAs collaborate with general physicians to perform patient examinations, diagnose and treat illnesses, prescribe medications, and perform other day-to-day medical services. Similar to a nurse practitioner, PAs can also practice independently of a physician in certain states.

Nurse Practitioner Scope of Practice

In 23 states, nurse practitioners have “full practice authority,” which means they do not have to work under the supervision of a doctor. US states with nurse practitioner full practice authority include but aren't limited to:

  • Oregon
  • Maine
  • Alaska
  • Hawaii
  • Washington
  • Iowa

In states with reduced practice (Ohio, Pennsylvania, and Utah) and restricted practice (Texas, California, and Florida), NPs must have a medical doctor sign certain medical patient care decisions. NPs have prescriptive privileges in all 50 states and can administer controlled substances in 49 states.

 


NP vs PA Career Outlook

According to the US Bureau of Labor Statistics, the need for nurse practitioners is expected to grow by 38% by 2033. This is much faster than the national average of other healthcare-related professions, including physician assistants, which are expected to grow in demand by 28%. 

NP vs PA Certification

As an NP, you must complete a recertification every five years by completing 1,000 clinical hours in your certified specialty and separate continuing education (CEU) hours. The PA recertification process has two parts, which includes 100 hours of continuing medical education (CME) hours every two years and a recertification exam every 10.


How to Choose Between Becoming a PA or an NP

NPs and PAs both provide direct patient care at the advanced practice level, including working independently or collaboratively. With so many baby boomers aging, the need for more graduate-level healthcare providers is increasing by the day. Plus, the need for these professions has escalated because of the Affordable Care Act, with more than 40 million more people added to the primary care systems after finally getting health insurance in the last two years.

“Physician assistants and nurse practitioners are more cost-effective in a health care system, and there has been an amazing up swell interest in how to integrate them into hospital systems in more and more ways,” says Jonathan Bowser, director and associate dean of the physician assistant program at the University of Colorado Anschutz Medical Campus.

Popular Online Nurse Practitioner (NP) Programs

Sponsored
Chamberlain University

Chamberlain University is the #1 largest school of nursing with a community of more than 177,000 students, faculty, and alumni. Chamberlain offers BSN, MSN, and DNP programs online and has a long history of successfully delivering top quality education.

Accreditation
CCNE
Location
Online
Prerequisite
RN Required

Enrollment: Nationwide

Walden University

Earn your nursing degree from one of the largest nursing education providers in the U.S. Walden University’s BSN, MSN, post-master’s APRN certificate, and DNP programs are accredited by the Commission on Collegiate Nursing Education (CCNE). Get enhanced practicum support with our Practicum Pledge.

Accreditation
CCNE
Location
Online
Prerequisite
RN Required

Enrollment: Nationwide, excluding CT, NY and RI. Certain programs have additional state restrictions. Check with Walden for details.

Georgetown University

Georgetown University is one of the world’s leading academic and research institutions, and the School of Nursing has been delivering graduate nursing programs in a distance-learning environment since 2011. Georgetown's online programs allow students to learn from wherever they are while they pursue an accredited, mission-driven nursing education that will allow them to deliver high-quality care.

Accreditation
CCNE
Location
Online
Prerequisite
RN Required

Enrollment: Nationwide, excluding NY and WA.

Western Governors University

WGU's award-winning online programs are created to help you succeed while graduating faster and with less debt. WGU is a CCNE-accredited, nonprofit university offering bachelor's and master's degrees in nursing, with the additional distinction of being named a Center of Excellence in Nursing Education by the National League for Nursing. Join a trusted, accredited online university to accelerate your nursing career on your schedule. Scholarships and financial aid are available. 

Accreditation
CCNE
Location
Online
Prerequisite
RN Required

Enrollment: Nationwide

FAQs

  • Is an NP higher than a PA? 

    • Both NPs and PAs are mid-level practitioners, but in many states, NPs can operate independently, while PAs can not. 
  • Is it better to see a physician's assistant or a nurse practitioner?

    • Both NPs and PAs can provide safe and quality care. NPs follow more of a nursing model with a focus on preventive health and education, while PAs are trained more in a medical model. 
  • What can a PA do that an NP cannot?

    •  Both PAs and NPs can assess and diagnose medical conditions, issue orders such as lab work and diagnostic tests, and prescribe medications. 
  • Can PAs intubate?

    • An emergency medicine PA can intubate a patient. 
  • Is a PA higher than an RN?

    • A PA and RN both work together as part of a healthcare team, but PAs can legally diagnose and order medications, while RNs cannot. 
Kathleen Gaines
MSN, RN, BA, CBC
Kathleen Gaines
News and Education Editor

Kathleen Gaines (nee Colduvell) is a nationally published writer turned Pediatric ICU nurse from Philadelphia with over 13 years of ICU experience. She has an extensive ICU background having formerly worked in the CICU and NICU at several major hospitals in the Philadelphia region. After earning her MSN in Education from Loyola University of New Orleans, she currently also teaches for several prominent Universities making sure the next generation is ready for the bedside. As a certified breastfeeding counselor and trauma certified nurse, she is always ready for the next nursing challenge.

Education:
MSN Nursing Education - Loyola University New Orleans
BSN - Villanova University
BA- University  of Mary Washington

Expertise:
Pediatric Nursing, Neonatal Nursing, Nursing Education, Women’s Health, Intensive Care, Nurse Journalism, Cardiac Nursing 

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